Steve Coogan

Steve (segment "Cousins?")

RZA

RZA (segment "Delirium")

Steve Buscemi

Danny (segment "Twins")

Alfred Molina

Alfred (segment "Cousins?")

Bill Murray

Bill Murray (segment "Delirium")

Cate Blanchett

Cate / Shelly (segment "Cousins")

Steven Wright

Steven (segment "Strange to Meet You")

Iggy Pop

Iggy (segment "Somewhere in California")

Jim Jarmusch

Director

Tom Waits

Tom (segment "Somewhere in California")

Joseph Rigano

Joe (segment "Those Things'll Kill Ya")

Isaach de Bankolé

Isaach (segment "No Problem")

Vinny Vella

Vinny (segment "Those Things'll Kill Ya")

Roberto Benigni

Roberto (segment "Strange to Meet You")

Joie Lee

Good Twin (segment "Twins")

Cinqué Lee

Evil Twin (segment "Twins") / Kitchen Guy (segment "Jack...")

Vinny Vella, Jr.

Vinny Jr. (segment "Those Things'll Kill Ya")

Renée French

Renée (segment "Renée")

E.J. Rodriguez

Waiter (segment "Renée")

Alex Descas

Alex (segment "No Problem")

Michael Hogan

Waiter (segment "Cousins")

Jack White

Jack (segment "Jack Shows Meg His Tesla Coil")

Meg White

Meg (segment "Jack Shows Meg His Tesla Coil")

Katy Hansz

Katy (segment "Cousins?")

The GZA

GZA (segment "Delirium")