Ralph Fiennes

Prof. James Moriarty / Jacob Musgrave

Will Ferrell

Sherlock Holmes

Rob Brydon

Inspector Lestrade

Kelly Macdonald

Mrs. Martha Hudson

John C. Reilly

Dr. John Watson

Pam Ferris

Queen Victoria

Etan Cohen

Writer

Bella Ramsey

Flotsam

Noah Jupe

Doxy

Rebecca Hall

Dr. Grace Hart

Lauren Lapkus

Millie

Nathan Osgood

Mark Twain

Michael Culkin

The Judge

Kieran O'Brien

PC Smalls

Chris Henchy

Executive Producer

Bronson Webb

Jonathan Nightingale

David Mimran

Executive Producer

Jordan Schur

Executive Producer

Jana Pérez

Lestrade's Wife

Jessica Elbaum

Executive Producer

Wolf Roth

Sigmund Freud

Ben Lee

Houdini

Matt Riley

Executive Producer

Paul Cassidy

Charlie Chaplin

Scarlet Grace

Pickle

David Shackleton

Albert Einstein

Adam Scherr

Brawn

Colby Mulgrew

Haybag

Billy Jenkins

Mud Fog

Jamie-Rose Monk

Mrs. Nightingale