Allison Janney

Lyla

Renée Zellweger

Betty

Chris Rock

Wesley

Crispin Glover

Roy

Moritz Borman

Executive Producer

Greg Kinnear

Dr. David Ravell

Morgan Freeman

Charlie

Pruitt Taylor Vince

Ballard

George D. Wallace

Grandfather

Philip Steuer

Executive Producer

Harriet Sansom Harris

Ellen

Steven Gilborn

Blake

Sheila Kelley

Joyce

Susan Barnes

Darlene

Alfonso Freeman

ER Doctor

Kathleen Wilhoite

Sue Ann

Aaron Eckhart

Del

Tia Texada

Rosa

Elizabeth Mitchell

Chloe

Matthew Cowles

Merle

Laird Macintosh

Dr. Lonnie Walsh

Neil LaBute

Director

Stephen Pevner

Executive Producer

Jenny Gago

Mercedes

Wayne Tippit

Doctor

Chris Sievernich

Executive Producer

Cynthia Martells

Chief Nurse

Sung-Hi Lee

Jasmine

Lesley Woods

Grandmother