John Lithgow

Sam Burns

David Wohl

Phil

Danny DeVito

Vernon Dahlart

Jeff Daniels

Flap Horton

Jack Nicholson

Garrett Breedlove

Troy Bishop

Tommy Horton

James L. Brooks

Director

Debra Winger

Emma Greenway Horton

Shirley MacLaine

Aurora Greenway

F. William Parker

Doctor

Lisa Hart Carroll

Patsy Clark

Betty King

Rosie Dunlop

Huckleberry Fox

Teddy Horton

Shane Serwin

Younger Tommy Horton

Megan Morris

Melanie Horton

Tara Yeakey

Baby Melanie

Norman Bennett

Edward Johnson

Jennifer Josey

Young Emma

Kate Charleson

Janice

Tom Wees

Dr. Budge

Paul Menzel

Dr. Maise

Amanda Watkins

Meg

Buddy Gilbert

Dr. Ratcher

Shelley K. Nielsen

Nurse

Bette Croissant

Nurse