David Oyelowo

The It (voice)

Chris Pine

Dr. Alex Murry

Oprah Winfrey

Mrs. Which

Michael Peña

Red

Zach Galifianakis

The Happy Medium

Reese Witherspoon

Mrs. Whatsit

Mindy Kaling

Mrs. Who

Will McCormack

Mr. Teacher

Bellamy Young

Camazotz Woman

Douglas C. Merrifield

Executive Producer

Gugu Mbatha-Raw

Dr. Kate Murry

Conrad Roberts

Elegant Man

Tim Kang

School Superintendent

Storm Reid

Meg Murry

André Holland

Principal Jenkins

Rowan Blanchard

Veronica Kiley

Ava DuVernay

Director

Levi Miller

Calvin O'Keefe

Daniel MacPherson

Calvin's Father

Akemi Look

Air Force Officer

Deric McCabe

Charles Wallace Murry

Lyric Wilson

Young Meg

Yvette Cason

Mrs. Teacher

Michele Norris

Radio News Broadcaster (voice)

Claire Montwill

Student

Catelynn Brown

Meg Double

Adam Borba

Executive Producer