Vernee Watson

Aunt Annette

Jenifer Lewis

Aunt Mary Williams (uncredited)

James Brolin

The Captain (uncredited)

Novella Nelson

Mrs. Tate

Sung Kang

Receptionist

Viola Davis

Eva May

Denzel Washington

Dr. Jerome Davenport

Derek Luke

Antwone Fisher

Malcolm David Kelley

Antwone Fisher Age 7

Cory Hodges

Antwone Fisher Age 14

Joy Bryant

Cheryl Smolley

Salli Richardson-Whitfield

Berta Davenport

Leonard Earl Howze

Pork Chop

Kente Scott

Kansas City

Kevin Connolly

Slim

Rainoldo Gooding

Grayson

Stephen Snedden

Berkley

Yolonda Ross

Nadine

Charles Robinson

Howard

Earl Billings

Uncle James

De'Angelo Wilson

Jesse

Kim Johnson

Disc Jockey

Leo Nepomuceno

SP #1

Cordell Stokes

Keith - Age 5

Antwone Fisher

Writer

Nancy Paloian

Executive Producer