Steve Carell

David Sheff

Timothy Hutton

Dr. Brown

Stefanie Scott

Julia

Jack Dylan Grazer

12-Year-Old Nic Sheff

Timothée Chalamet

Nic Sheff

Christian Convery

Jasper Sheff

Sarah Esberg

Executive Producer

Maura Tierney

Karen Barbour

LisaGay Hamilton

Rose

Andre Royo

Spencer

Amy Ryan

Vicki Sheff

Amy Aquino

Annie Goldblum

Nan Morales

Executive Producer

Kaitlyn Dever

Lauren

Mandeiya Flory

Kid

Amy Forsyth

Diane

Kue Lawrence

5-Year-Old Nic Sheff

Julian Works

Gack

Oakley Bull

Daisy Sheff

Zachary Rifkin

8-Year-Old Nic Sheff

Ricky Low

Destiny

Carlton Wilborn

Vince

Marypat Farrell

Julia's Mother

Brandon James Cienfuegos

Kid

Cheska Corona

Kid

Martha T. Newman

Flight Attendant

Felix van Groeningen

Director