Keith David

Kupaka / Joe Napier / An-kor Apis / Prescient

Hugo Weaving

Haskell Moore / Tadeusz Kesselring / Bill Smoke / Nurse Noakes / Boardman Mephi / Old Georgie

Tom Hanks

Dr. Henry Goose / Hotel Manager / Isaac Sachs / Dermot Hoggins / Cavendish Look-a-Like Actor / Zachry

Susan Sarandon

Madame Horrox / Older Ursula / Yusouf Suleiman / Abbess

Lilly Wachowski

Director

Lana Wachowski

Director

Halle Berry

Native Woman / Jocasta Ayrs / Luisa Rey / Indian Party Guest / Ovid / Meronym

Jim Broadbent

Captain Molyneux / Vyvyan Ayrs / Timothy Cavendish / Korean Musician / Prescient 2

Jim Sturgess

Adam Ewing / Poor Hotel Guest / Megan's Dad / Highlander / Hae-Joo Chang / Adam / Zachry Brother-in-Law

Robert Fyfe

Old Salty Dog / Mr. Meeks / Prescient 1

Zhou Xun

Talbot / Hotel Manager / Yoona-939 / Rose

Hugh Grant

Rev. Giles Horrox / Hotel Heavy / Lloyd Hooks / Denholme Cavendish / Seer Rhee / Kona Chief

Philip Lee

Executive Producer

James D'Arcy

Young Rufus Sixsmith / Old Rufus Sixsmith / Nurse James / Archivist

Andrew Havill

Mr. Hotchkiss

Ralph Riach

Ernie

Tom Tykwer

Director

Ben Whishaw

Cabin Boy / Robert Frobisher / Store Clerk / Georgette / Tribesman

Amanda Walker

Veronica

Martin Wuttke

Mr. Boerhaave / Guard / Leary the Healer

David Gyasi

Autua / Lester Rey / Duophsyte

Götz Otto

Groundsman Withers

Pearry Reginald Teo

Executive Producer

Bae Doona

Tilda / Megan's Mom / Mexican Woman / Sonmi-451 / Sonmi-351 / Sonmi Prostitute

Uwe Schott

Executive Producer

John Chong

Executive Producer

Brody Nicholas Lee

Javier Gomez / Jonas / Zachry's Older Nephew

Peter Lam Kin-Ngok

Executive Producer

Robin Morrissey

Young Cavendish

Ian van Temperley

Enforcer

Tanja de Wendt

Mrs. Hotchkiss

Raevan Lee Hanan

Little Girl with Orison at Papa Song's / Catkin / Zachry Relative

Wilson Qiu

Executive Producer

Ricky Tse

Executive Producer

Tony Teo

Executive Producer

Caroline Kwauk

Executive Producer