Helena Bonham Carter

Eudoria Holmes

Alex Kelly

Miss Gregory II

Burn Gorman

Linthorn

Susan Wokoma

Edith

Adeel Akhtar

Lestrade

Millie Bobby Brown

Enola Holmes

Henry Cavill

Sherlock Holmes

Hattie Morahan

Lady Tewkesbury

Fiona Shaw

Miss Harrison

Claire Rushbrook

Mrs. Lane

Neil Bell

Constable

Frances de la Tour

The Dowager

Sam Claflin

Mycroft Holmes

Louis Partridge

Lord Tewkesbury

David Bamber

Sir Whimbrel

Gaby French

Seamstress

Paul Copley

Station Master

Ellie Haddington

Miss Gregory

James Duke

Footman

Connor Catchpole

Gardener

Sarah Flind

Tea Shop Assistant

Dempsey Bovell

Fleet Street Hawker

Sofia Stavrinou

Young Enola

Sophie Dixon

Toddler Enola

Harry Bradbeer

Director

Michael Dreyer

Executive Producer

Joshua Grode

Executive Producer