Robert De Niro

Jack Byrnes

Owen Wilson

Kevin Rawley

Ben Stiller

Greg Focker

Peter Bartlett

Animal Shelter Worker

Judah Friedlander

Pharmacy Clerk

John Fiore

Kinky

James Rebhorn

Dr. Larry Banks

Teri Polo

Pam Byrnes

Jay Roach

Director

Blythe Danner

Dina Byrnes

Jon Abrahams

Denny Byrnes

Russell Hornsby

Late Night Courier

Nicole DeHuff

Debbie Byrnes

Tom McCarthy

Dr. Bob Banks

Phyllis George

Linda Banks

Kali Rocha

Flight Attendant

Bernie Sheredy

Norm the Interrogator

John Elsen

Chicago Airport Security

Mark Hammer

Hospital Patient

Amy Hohn

Ticket Agent

William Severs

Father O'Boyle

Marilyn Dobrin

Kali Rocha

Marci Reid

Traveler

Frank Santorelli

Courier

Patricia Cook

Little Girl