Danny Trejo

Cucuy

Cheech Marin

Belini

Antonio Banderas

El Mariachi

Willem Dafoe

Armando Barillo

Troy Robinson

Romero

Johnny Depp

CIA Agent Jeffrey Sands

Salma Hayek Pinault

Carolina

Mickey Rourke

Billy Chambers

Tito Larriva

Cab Driver

Robert Rodriguez

Director

Rubén Blades

Jorge, Retired FBI Agent

Julio Oscar Mechoso

Nicholas, Presidential Advisor

Eva Mendes

CIA Agent Ajedrez

Enrique Iglesias

Lorenzo

Marco Leonardi

Fideo

Gerardo Vigil

General Marquez

Pedro Armendáriz Jr.

President of Mexico

Miguel Couturier

Dr. Guevera

Tony Valdes

Chicle Boy

José Luis Avendaño

Alvaro

Rodolfo De Alexandre

Omar

Natália Torres

El Mariachi's Daughter

Steve Constancio

Right Hand

Ermahn Ospina

Qui-Que

Luz María Rojas

Pistolera