David Hyde Pierce

Dennis Reed

Rob Reiner

Jay

Tom Hanks

Sam Baldwin

Victor Garber

Greg

Meg Ryan

Annie Reed

Rosie O'Donnell

Becky

Bill Pullman

Walter

Frances Conroy

Irene Reed

Calvin Trillin

Uncle Milton

Tom Riis Farrell

Rob

Ross Malinger

Jonah Baldwin

Barbara Garrick

Victoria

Gaby Hoffmann

Jessica

Rita Wilson

Suzy

Carey Lowell

Maggie Baldwin

Le Clanché du Rand

Barbara Reed

Kevin O'Morrison

Cliff Reed

Valerie Wright

Betsy Reed

Tom Tammi

Harold Reed

Caroline Aaron

Dr. Marcia Fieldstone

Linda Wallem

Loretta

LaTanya Richardson Jackson

Harriet

Tom McGowan

Keith

Steve Mellor

Wyatt

Nora Ephron

Director

Patrick Crowley

Executive Producer

Lynda Obst

Executive Producer